JNIS Podcast

Cerebrovascular pulsatile tinnitus: causes, treatments, and outcomes

In this podcast, JNIS Editor-in-Chief, Dr. Felipe C. Albuquerque, speaks with Dr. Matthew Amans(1) and Daniel Cummins(2) about their paper "Cerebrovascular pulsatile tinnitus: causes, treatments, and outcomes in 164 patients with neuroangiographic correlation" - https://jnis.bmj.com/content/early/2022/09/08/jnis-2022-019259.
Please subscribe to the JNIS Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest episodes. Also, please consider leaving us a review or a comment on the JNIS Podcast iTunes page: https://podcasts.apple.com/gb/podcast/jnis-podcast/id942473767
Thank you for listening!
This episode was edited by Brian O'Toole.
(1) School of Medicine, University of California, San Francisco, USA
(2) Radiology and Biomedical Imaging, University of California, San Francisco, USA

Nationwide rAVM discharge incidence is inversely correlated with uAVM intervention rate

The 2013 ARUBA trial concluded that medical management alone is superior to medical management with interventional therapy for patients with unruptured brain arteriovenous malformations. A study was conducted to analyze AVM treatment and epidemiologic response to the ARUBA trial. Following ARUBA, there has been a stark decrease in interventions for uAVMs. Nationwide rAVM discharge incidence is inversely correlated with uAVM intervention rate. Less uAVM interventions may lead to a substantial increase in AVM rupture incidence.
In this podcast, JNIS Editor-in-Chief, Dr. Felipe C. Albuquerque speaks with Dr. Evan Luther(1) and Dr. Robert Starke(2) about their paper "Unruptured arteriovenous malformation intervention rate is inversely correlated with ruptured AVM discharge incidence" - https://jnis.bmj.com/content/12/suppl_1/a163.
Please subscribe to the JNIS Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest episodes. Also, please consider leaving us a review or a comment on the JNIS Podcast iTunes page: https://podcasts.apple.com/gb/podcast/jnis-podcast/id942473767
Thank you for listening!
This episode was produced by Leticia Amorim and edited by Brian O'Toole.
(1) Neurological Surgery, University of Miami, Miami, Florida, USA
(2) Department of Neurosurgery & Radiology, Miller School of Medicine, University of Miami, Miami, Florida, USA

Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of brain tumors

Survival for glioblastoma remains very poor despite decades of research, with a 5-year survival of only 5%. Technological improvements that have revolutionized treatment of ischemic stroke and brain aneurysms have great potential in providing more precise and selective delivery of cancer therapeutic agents to brain tumors.
In this podcast, JNIS Editor-in-Chief, Dr. Felipe C. Albuquerque speaks with Dr. Stephen Chen (1)and Dr. Peter Kan (2) about their paper "Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors". The paper describes a technique using perfusion guidance to enhance the precision of endovascular super-selective intra-arterial (ESIA) infusions of mesenchymal stem cells loaded with Delta-24 in the treatment of glioblastoma. This technique enhances targeted super-selective delivery of therapeutic agents for brain tumors.
Paper available online (https://jnis.bmj.com/content/14/6/533) and in June print issue of JNIS.
Please subscribe to the JNIS Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest episodes. Also, please consider leaving us a review or a comment on the JNIS Podcast iTunes page: https://podcasts.apple.com/gb/podcast/jnis-podcast/id942473767
Thank you for listening!
This episode was produced by Leticia Amorim and edited by Brian O'Toole.
(1) Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
(2) Neurosurgery, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA

Comparing treatment outcomes of intracranial bifurcation aneurysms locations using the WEB device

The Woven EndoBridge (WEB) device has FDA approval for treatment of wide-necked intracranial bifurcation aneurysms. It has been shown to result in adequate occlusion in bifurcation aneurysms overall, but its usefulness in the individual bifurcation locations has been evaluated separately only in few case series, which were limited by small sample sizes.
In this podcast, JNIS Editor-in-Chief, Dr. Felipe C. Albuquerque, interviews Dr. Nimer Adeeb (1)and Dr. Adam Dmytriw (2) on their paper "Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device".
Paper available online: https://jnis.bmj.com/content/early/2022/04/27/neurintsurg-2022-018694
Please subscribe to the JNIS Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest episodes. Also, please consider leaving us a review or a comment on the JNIS Podcast iTunes page: https://podcasts.apple.com/gb/podcast/jnis-podcast/id942473767
Thank you for listening!
This episode was edited by Brian O'Toole.
(1) Departments of Neurosurgery and Neurointerventional Surgery, Louisiana State University Health Sciences Center
(2)Neuroendovascular Program, Massachusetts General Hospital, Harvard University

Sex differences in endovascular thrombectomy outcomes in large vessel occlusion

Sex disparities in acute ischemic stroke outcomes are well reported with IV thrombolysis. Despite several studies, there is still a lack of consensus on whether endovascular thrombectomy (EVT) outcomes differ between men and women.
In this podcast, we discuss the Selection for Endovascular Treatment in Acute Ischemic Stroke (SELECT) study, in which women had similar discharge outcomes as men following EVT, in a propensity-matched cohort, but the improvement from discharge to 90 days was significantly worse in women, suggesting the influence of post-discharge factors.
JNIS Editor-in-Chief, Dr. Felipe C. Albuquerque, interviews Johanna Fifi (Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York) and Amrou Sarraj (Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio).
Paper available online: https://jnis.bmj.com/content/early/2022/02/28/neurintsurg-2021-018348.
Please subscribe to the JNIS Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest episodes. Also, please consider leaving us a review or a comment on the JNIS Podcast iTunes page: https://podcasts.apple.com/gb/podcast/jnis-podcast/id942473767.
Thank you for listening!

ESO-ESMINT expedited recommendation on intravenous thrombolysis before mechanical thrombectomy

In the latest podcast, we discuss the joint expedited recommendations from the European Stroke Organisation (ESO) and the European Society for Minimally Invasive Neurological Therapy (ESMINT) on indication for intravenous thrombolysis before mechanical thrombectomy in patients with acute ischemic stroke and anterior circulation large vessel occlusion.
JNIS Editor-in-Chief, Dr. Felipe C. Albuquerque, interviews Dr. Guillaume Turc, Department of Neurology, GHU Paris Psychiatrie et Neurosciences, Université de Paris, and co-chair of the module working group.
Paper available here: https://jnis.bmj.com/content/14/3/209.
Please subscribe to the JNIS Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest episodes. Also, please consider leaving us a review or a comment on the JNIS Podcast iTunes page: https://podcasts.apple.com/gb/podcast/jnis-podcast/id942473767.
Thank you for listening!

Major complications of dural venous sinus stenting for idiopathic intracranial hypertension

Venous sinus stenting (VSS) is a safe, effective, and increasingly popular treatment option for selected patients with idiopathic intracranial hypertension (IIH). Serious complications associated with VSS are rarely reported.
In this podcast, JNIS Editor-in-Chief, Felipe C. Albuquerque, interviews Dr. Kyle Fargen, from the Department of Neurosurgery, Wake Forest University, Winston-Salem, North Carolina, about a case series in which serious complications after VSS were identified retrospectively from multicenter databases. The cases are reviewed and learning points regarding complication avoidance and management are presented in his paper (https://jnis.bmj.com/content/early/2021/04/27/neurintsurg-2021-017361).

COMPASS: intravenous ateplase and the efficacy of aspiration vs. stent retriever thrombectomy

In this podcast, we discuss the COMPASS: a trial of aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion, comparing patients with and without prior intravenous (IV) alteplase administration.
JNIS Editor-in-Chief, Felipe C. Albuquerque, interviews Maxim Mokin, from the Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, USA, about the post hoc analysis. which concludes that prior administration of IV alteplase may adversely affect the efficacy of aspiration, whilst it does not seem to influence the stent retriever first approach to MT in patients with anterior circulation ELVO.
Read the related paper on the JNIS website: https://jnis.bmj.com/content/early/2021/10/13/neurintsurg-2021-017943

Long-term angiographic follow-up following Pipeline embolization of intracranial aneurysms

Flow diversion of intracranial aneurysms with the Pipeline Embolization Device (PED) is commonly performed, but the value of long-term angiographic follow-up has not been rigorously evaluated. The study discussed in this podcast examines the prevalence of actionable findings of aneurysm recurrence and development of in-stent stenosis in a cohort of patients that underwent long-term angiographic follow-up at multiple time points.
JNIS Editor-In-Chief, Felipe C. Albuquerque, interviews Dr Akash P. Kansagra, from the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, USA.
Related paper: https://jnis.bmj.com/content/early/2021/07/01/neurintsurg-2021-017745

Ophthalmic artery occlusion in intra-arterial chemotherapy for retinoblastoma

Retinoblastoma is the most common primary intraocular malignancy in children.
In this podcast, JNIS Editor-In-Chief Felipe C. Albuquerque and Pascal Jabbour discuss a study from July’s issue, concluding that local factors relating to the chemotherapy and selective microcatheterization of the ophthalmic artery are essential factors in the development of ophthalmic artery thrombosis, as seen by the association of ophthalmic artery thrombosis with the frequency of intra-arterial chemotherapy.
Dr Jabbour, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, USA, is the corresponding author of 'Incidence and predictors of ophthalmic artery occlusion in intra-arterial chemotherapy for retinoblastoma' - https://jnis.bmj.com/content/13/7/652